{"id":2901,"date":"2024-03-29T12:27:49","date_gmt":"2024-03-29T03:27:49","guid":{"rendered":"https:\/\/neumed042.mycafe24.com\/?page_id=2901"},"modified":"2024-05-31T15:21:03","modified_gmt":"2024-05-31T06:21:03","slug":"%ec%97%b0%ea%b5%ac%ec%84%b1%ea%b3%bc","status":"publish","type":"page","link":"https:\/\/ht042.co.kr\/en\/%ec%97%b0%ea%b5%ac%ec%84%b1%ea%b3%bc\/","title":{"rendered":"\uc5f0\uad6c\uc131\uacfc"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"2901\" class=\"elementor elementor-2901\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8e7681b e-flex e-con-boxed e-con e-parent\" data-id=\"8e7681b\" data-element_type=\"container\" data-core-v316-plus=\"true\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d745fd7 history-tab-wrapper elementor-tabs-view-horizontal elementor-widget elementor-widget-tabs\" data-id=\"d745fd7\" data-element_type=\"widget\" data-widget_type=\"tabs.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.20.0 - 26-03-2024 *\/\n.elementor-widget-tabs.elementor-tabs-view-vertical .elementor-tabs-wrapper{width:25%;flex-shrink:0}.elementor-widget-tabs.elementor-tabs-view-vertical .elementor-tab-desktop-title.elementor-active{border-right-style:none}.elementor-widget-tabs.elementor-tabs-view-vertical .elementor-tab-desktop-title.elementor-active:after,.elementor-widget-tabs.elementor-tabs-view-vertical .elementor-tab-desktop-title.elementor-active:before{height:999em;width:0;right:0;border-right-style:solid}.elementor-widget-tabs.elementor-tabs-view-vertical .elementor-tab-desktop-title.elementor-active:before{top:0;transform:translateY(-100%)}.elementor-widget-tabs.elementor-tabs-view-vertical .elementor-tab-desktop-title.elementor-active:after{top:100%}.elementor-widget-tabs.elementor-tabs-view-horizontal .elementor-tab-desktop-title{display:table-cell}.elementor-widget-tabs.elementor-tabs-view-horizontal .elementor-tab-desktop-title.elementor-active{border-bottom-style:none}.elementor-widget-tabs.elementor-tabs-view-horizontal .elementor-tab-desktop-title.elementor-active:after,.elementor-widget-tabs.elementor-tabs-view-horizontal .elementor-tab-desktop-title.elementor-active:before{bottom:0;height:0;width:999em;border-bottom-style:solid}.elementor-widget-tabs.elementor-tabs-view-horizontal .elementor-tab-desktop-title.elementor-active:before{right:100%}.elementor-widget-tabs.elementor-tabs-view-horizontal .elementor-tab-desktop-title.elementor-active:after{left:100%}.elementor-widget-tabs .elementor-tab-content,.elementor-widget-tabs .elementor-tab-title,.elementor-widget-tabs .elementor-tab-title:after,.elementor-widget-tabs .elementor-tab-title:before,.elementor-widget-tabs .elementor-tabs-content-wrapper{border:1px #d5d8dc}.elementor-widget-tabs .elementor-tabs{text-align:left}.elementor-widget-tabs .elementor-tabs-wrapper{overflow:hidden}.elementor-widget-tabs .elementor-tab-title{cursor:pointer;outline:var(--focus-outline,none)}.elementor-widget-tabs .elementor-tab-desktop-title{position:relative;padding:20px 25px;font-weight:700;line-height:1;border:solid transparent}.elementor-widget-tabs .elementor-tab-desktop-title.elementor-active{border-color:#d5d8dc}.elementor-widget-tabs .elementor-tab-desktop-title.elementor-active:after,.elementor-widget-tabs .elementor-tab-desktop-title.elementor-active:before{display:block;content:\"\";position:absolute}.elementor-widget-tabs .elementor-tab-desktop-title:focus-visible{border:1px solid #000}.elementor-widget-tabs .elementor-tab-mobile-title{padding:10px;cursor:pointer}.elementor-widget-tabs .elementor-tab-content{padding:20px;display:none}@media (max-width:767px){.elementor-tabs .elementor-tab-content,.elementor-tabs .elementor-tab-title{border-style:solid solid none}.elementor-tabs .elementor-tabs-wrapper{display:none}.elementor-tabs .elementor-tabs-content-wrapper{border-bottom-style:solid}.elementor-tabs .elementor-tab-content{padding:10px}}@media (min-width:768px){.elementor-widget-tabs.elementor-tabs-view-vertical .elementor-tabs{display:flex}.elementor-widget-tabs.elementor-tabs-view-vertical .elementor-tabs-wrapper{flex-direction:column}.elementor-widget-tabs.elementor-tabs-view-vertical .elementor-tabs-content-wrapper{flex-grow:1;border-style:solid solid solid none}.elementor-widget-tabs.elementor-tabs-view-horizontal .elementor-tab-content{border-style:none solid solid}.elementor-widget-tabs.elementor-tabs-alignment-center .elementor-tabs-wrapper,.elementor-widget-tabs.elementor-tabs-alignment-end .elementor-tabs-wrapper,.elementor-widget-tabs.elementor-tabs-alignment-stretch .elementor-tabs-wrapper{display:flex}.elementor-widget-tabs.elementor-tabs-alignment-center .elementor-tabs-wrapper{justify-content:center}.elementor-widget-tabs.elementor-tabs-alignment-end .elementor-tabs-wrapper{justify-content:flex-end}.elementor-widget-tabs.elementor-tabs-alignment-stretch.elementor-tabs-view-horizontal .elementor-tab-title{width:100%}.elementor-widget-tabs.elementor-tabs-alignment-stretch.elementor-tabs-view-vertical .elementor-tab-title{height:100%}.elementor-tabs .elementor-tab-mobile-title{display:none}}<\/style>\t\t<div class=\"elementor-tabs\">\n\t\t\t<div class=\"elementor-tabs-wrapper\" role=\"tablist\" >\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-2251\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"true\" data-tab=\"1\" role=\"tab\" tabindex=\"0\" aria-controls=\"elementor-tab-content-2251\" aria-expanded=\"false\">Functionality<\/div>\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-2252\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"false\" data-tab=\"2\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2252\" aria-expanded=\"false\">Safety<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t<div class=\"elementor-tabs-content-wrapper\" role=\"tablist\" aria-orientation=\"vertical\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"true\" data-tab=\"1\" role=\"tab\" tabindex=\"0\" aria-controls=\"elementor-tab-content-2251\" aria-expanded=\"false\">Functionality<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-2251\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2251\" tabindex=\"0\" hidden=\"false\">\t\t<div data-elementor-type=\"section\" data-elementor-id=\"3067\" class=\"elementor elementor-3067\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6960b45 sub_company_info_type4_bg elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6960b45\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-0b5f119\" data-id=\"0b5f119\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-874107c elementor-widget__width-initial elementor-invisible elementor-widget elementor-widget-image\" data-id=\"874107c\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;slideInRight&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.20.0 - 26-03-2024 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"516\" height=\"1024\" src=\"https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/HT042\uac00-\ubbf8\uce58\ub294-\uc601\ud5a5-\ubaa8\uc2dd\ub3c4\uc218\uc815\ubcf8-516x1024.jpg\" class=\"attachment-large size-large wp-image-3517\" alt=\"\" srcset=\"https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/HT042\uac00-\ubbf8\uce58\ub294-\uc601\ud5a5-\ubaa8\uc2dd\ub3c4\uc218\uc815\ubcf8-516x1024.jpg 516w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/HT042\uac00-\ubbf8\uce58\ub294-\uc601\ud5a5-\ubaa8\uc2dd\ub3c4\uc218\uc815\ubcf8-151x300.jpg 151w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/HT042\uac00-\ubbf8\uce58\ub294-\uc601\ud5a5-\ubaa8\uc2dd\ub3c4\uc218\uc815\ubcf8-768x1525.jpg 768w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/HT042\uac00-\ubbf8\uce58\ub294-\uc601\ud5a5-\ubaa8\uc2dd\ub3c4\uc218\uc815\ubcf8-773x1536.jpg 773w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/HT042\uac00-\ubbf8\uce58\ub294-\uc601\ud5a5-\ubaa8\uc2dd\ub3c4\uc218\uc815\ubcf8-200x397.jpg 200w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/HT042\uac00-\ubbf8\uce58\ub294-\uc601\ud5a5-\ubaa8\uc2dd\ub3c4\uc218\uc815\ubcf8-500x993.jpg 500w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/HT042\uac00-\ubbf8\uce58\ub294-\uc601\ud5a5-\ubaa8\uc2dd\ub3c4\uc218\uc815\ubcf8-800x1589.jpg 800w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/HT042\uac00-\ubbf8\uce58\ub294-\uc601\ud5a5-\ubaa8\uc2dd\ub3c4\uc218\uc815\ubcf8.jpg 949w\" sizes=\"(max-width: 516px) 100vw, 516px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-eb3a0ac elementor-invisible\" data-id=\"eb3a0ac\" data-element_type=\"column\" data-settings=\"{&quot;animation&quot;:&quot;fadeInRight&quot;,&quot;animation_delay&quot;:200}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-23055a4 elementor-widget elementor-widget-text-editor\" data-id=\"23055a4\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.20.0 - 26-03-2024 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<h4>Through various studies, <br>we verified that <span style=\"background-color: #fff8b2; line-height: 150%;\">HT042 improves height growth rate.<\/span><\/h4>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3ac863e elementor-widget elementor-widget-text-editor\" data-id=\"3ac863e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h5><span style=\"font-weight: bold;\">How does height grow?<\/span><\/h5>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7d3526c elementor-widget elementor-widget-text-editor\" data-id=\"7d3526c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\u2460 Growth hormone secreted by the brain synthesizes growth factors in the liver.\n<br>\u2461 The synthesized growth factor combines with growth protein and <br>\u2462 moves to the growth plate at the tip of the bone.\n<br>\u2463 When growth factors act on the growth plate,\n<br>\u2464 increase the number and size of chondrocytes in the growth plate, resulting in longer bones and taller bones.\n\n<br><br>In summary, <span style=\"font-weight: bold;\">growth hormone increases growth factors and growth proteins, which eventually makes you taller.<\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6d868c5 elementor-widget elementor-widget-text-editor\" data-id=\"6d868c5\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h5><span style=\"font-weight: bold;\">How can HT042 help you grow taller?<\/span><\/h5>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c498fda elementor-widget elementor-widget-text-editor\" data-id=\"c498fda\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\tHT042 <span style=\"font-weight: bold;\">helps the synthesis of growth factors and growth proteins in the liver <\/span>during the above process.\nTherefore, it <span style=\"font-weight: bold;\">increases the number of growth factors and growth proteins going to the growth plate.<\/span>\n<br><br>\nAs a result, <span style=\"font-weight: bold;\">taking HT042 increases the number and size of chondrocytes in the growth plate,<\/span>which can help in height growth.\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-72d9dfb elementor-widget elementor-widget-text-editor\" data-id=\"72d9dfb\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\tRead more below for more in-depth and interesting findings.\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t<div class=\"elementor-element elementor-element-25d6f06 e-flex e-con-boxed e-con e-parent\" data-id=\"25d6f06\" data-element_type=\"container\" data-core-v316-plus=\"true\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-86efcf8 e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"86efcf8\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;animation&quot;:&quot;fadeInUp&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-09a6f95 e-con-full e-flex e-con e-child\" data-id=\"09a6f95\" data-element_type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;none&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c000969 elementor-widget elementor-widget-image\" data-id=\"c000969\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"669\" height=\"866\" src=\"https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_5-11.-J-Med-Food-2010.jpg\" class=\"attachment-large size-large wp-image-3167\" alt=\"\" srcset=\"https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_5-11.-J-Med-Food-2010.jpg 669w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_5-11.-J-Med-Food-2010-232x300.jpg 232w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_5-11.-J-Med-Food-2010-200x259.jpg 200w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_5-11.-J-Med-Food-2010-500x647.jpg 500w\" sizes=\"(max-width: 669px) 100vw, 669px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5341a33 e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"5341a33\" data-element_type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeInUp&quot;,&quot;animation_delay&quot;:300}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b537004 mb-0 elementor-widget elementor-widget-heading\" data-id=\"b537004\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.20.0 - 26-03-2024 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h5 class=\"elementor-heading-title elementor-size-default\">The herbal formula HT042 induces longitudinal bone growth in adolescent female rats<\/h5>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-12acffe mb-0 elementor-widget elementor-widget-heading\" data-id=\"12acffe\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\">J Med Food, 2010<\/h6>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0111fb4 mb-1 elementor-widget elementor-widget-heading\" data-id=\"0111fb4\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<p class=\"elementor-heading-title elementor-size-default\"><span class=\"fw-bold\">HT042 accelerates the growth rate of bone length in rats.<\/span>\n<br>[Reported that HT042 has the effect of promoting the growth rate of bone length in rats, the effect of promoting the growth of growth plate chondrocytes, the effect of increasing the length of the growth plate proliferative part, and the effect of increasing the expression of IGF-1 and BMP-2 in growth plate]<br><br>\nAfter oral administration of HT042 to 3-week-old female SD rats for 4 days, the growth rate was measured by tetracycline calcium fluorescence labeling method. As a result, the growth rate was significantly increased to a similar extent to growth hormone.<br>\nIn addition, the number of chondrocytes in the tibial growth plate and the thickness of the proliferative zone were increased, and the expression of IGF-1 and BMP-2 was increased.<\/p>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-05da942 e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"05da942\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;animation&quot;:&quot;fadeInUp&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-5c3330b e-con-full e-flex e-con e-child\" data-id=\"5c3330b\" data-element_type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;none&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c241753 elementor-widget elementor-widget-image\" data-id=\"c241753\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"669\" height=\"947\" src=\"https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_5-12.-Phytother-Res-2012.jpg\" class=\"attachment-large size-large wp-image-3168\" alt=\"\" srcset=\"https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_5-12.-Phytother-Res-2012.jpg 669w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_5-12.-Phytother-Res-2012-212x300.jpg 212w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_5-12.-Phytother-Res-2012-200x283.jpg 200w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_5-12.-Phytother-Res-2012-500x708.jpg 500w\" sizes=\"(max-width: 669px) 100vw, 669px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-12b0a71 e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"12b0a71\" data-element_type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeInUp&quot;,&quot;animation_delay&quot;:300}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b304eac mb-0 elementor-widget elementor-widget-heading\" data-id=\"b304eac\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Skeletal growth and IGF levels in rats after HT042 treatment<\/h5>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0c6f375 mb-0 elementor-widget elementor-widget-heading\" data-id=\"0c6f375\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\">Phytother Res, 2012<\/h6>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fc7ad48 mb-1 elementor-widget elementor-widget-heading\" data-id=\"fc7ad48\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<p class=\"elementor-heading-title elementor-size-default\"><span class=\"fw-bold\">HT042 accelerates the body length growth rate of rats.<\/span><br>\n[Reported that HT042 has the effect of increasing the body length of rats, the effect of increasing the length of the growth plate hypertrophy, and the effect of increasing the expression of IGF-1 and IGFBP-3 in growth plate]<br><br>\nAfter oral administration of HT042 to 8-week-old female SD rats for 3 weeks, the length from the nose to the tail was measured. As a result, the body length was significantly increased to a similar extent to growth hormone.<br> Also, the thickness of the hypertrophic part of the tibial growth plate was increased, and the expression of IGF-1 and IGFBP-3 was increased.<br><\/p>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2b7a07b e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"2b7a07b\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;animation&quot;:&quot;fadeInUp&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-c7a5dc2 e-con-full e-flex e-con e-child\" data-id=\"c7a5dc2\" data-element_type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;none&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9d84dce elementor-widget elementor-widget-image\" data-id=\"9d84dce\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"669\" height=\"946\" src=\"https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_5-13.-Molecules-2013.jpg\" class=\"attachment-large size-large wp-image-3169\" alt=\"\" srcset=\"https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_5-13.-Molecules-2013.jpg 669w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_5-13.-Molecules-2013-212x300.jpg 212w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_5-13.-Molecules-2013-200x283.jpg 200w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_5-13.-Molecules-2013-500x707.jpg 500w\" sizes=\"(max-width: 669px) 100vw, 669px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3767ded e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"3767ded\" data-element_type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeInUp&quot;,&quot;animation_delay&quot;:300}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6e887f8 mb-0 elementor-widget elementor-widget-heading\" data-id=\"6e887f8\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Effect of HT042, herbal formula, on longitudinal bone growth in spontaneous dwarf rats\n<\/h5>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-489f362 mb-0 elementor-widget elementor-widget-heading\" data-id=\"489f362\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\">Molecules, 2013\n<\/h6>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c27143c mb-1 elementor-widget elementor-widget-heading\" data-id=\"c27143c\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<p class=\"elementor-heading-title elementor-size-default\"><span class=\"fw-bold\">The growth-promoting effect of HT042 appears in the growth hormone secretion-stimulating pathway.<\/span><br>\n[Reported that HT042 acts as a pathway to promote growth hormone secretion, as HT042 does not show growth-promoting effects in spontaneous dwarfism rats]<br><br>\nHT042 was orally administered to male and female rats with spontaneous dwarfism which is unable to produce normal growth hormone for 10 days, and the growth rate was measured by tetracycline calcium fluorescence labeling method. Unlike normal rats, the growth-promoting effect of HT042 was not shown, so it was judged that HT042 acted as a growth hormone secretion-stimulating pathway.<br><\/p>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2649d15 e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"2649d15\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;animation&quot;:&quot;fadeInUp&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-786f833 e-con-full e-flex e-con e-child\" data-id=\"786f833\" data-element_type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;none&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6750147 elementor-widget elementor-widget-image\" data-id=\"6750147\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"669\" height=\"945\" src=\"https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_5-14.-Molecules-2016.jpg\" class=\"attachment-large size-large wp-image-3170\" alt=\"\" srcset=\"https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_5-14.-Molecules-2016.jpg 669w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_5-14.-Molecules-2016-212x300.jpg 212w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_5-14.-Molecules-2016-200x283.jpg 200w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_5-14.-Molecules-2016-500x706.jpg 500w\" sizes=\"(max-width: 669px) 100vw, 669px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e40163f e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"e40163f\" data-element_type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeInUp&quot;,&quot;animation_delay&quot;:300}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-05fa8d0 mb-0 elementor-widget elementor-widget-heading\" data-id=\"05fa8d0\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Effects of Phlomis umbrosa Root on Longitudinal Bone Growth Rate in Adolescent Female Rats\n<\/h5>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d0ba0e6 mb-0 elementor-widget elementor-widget-heading\" data-id=\"d0ba0e6\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\">Molecules, 2016\n<\/h6>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-01c87da mb-1 elementor-widget elementor-widget-heading\" data-id=\"01c87da\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<p class=\"elementor-heading-title elementor-size-default\"><span class=\"fw-bold\">Phlomis umbrosa extract, a component of HT042, accelerates the growth rate of bone length in rats.<\/span><br>\n[Reported that Phlomis umbrosa extract has the effect of promoting the growth rate of bone length in rats, the effect of promoting the growth plate chondrocyte proliferation, the effect of increasing the expression of IGF-1 and BMP-2 in growth plate, and the secretion of IGFBP-3 in the blood]<br><br>\nPhlomis umbrosa extract was orally administered to 25-day-old female SD rats for 10 days, and the growth rate was measured by tetracycline calcium fluorescence labeling method. As a result, the growth rate was significantly increased in a dose-dependent manner.<br> \nIn addition, the number of chondrocytes in the tibial growth plate and the thickness of the hypertrophic zone were increased, and the expression of IGF-1 and BMP-2 was increased.<br>\nAs a result of measuring blood concentration at 12 hours after administration of Phlomis umbrosa extract, IGFBP-3 was significantly increased.<\/p>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f4e38c4 e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"f4e38c4\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;animation&quot;:&quot;fadeInUp&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-9cfa1af e-con-full e-flex e-con e-child\" data-id=\"9cfa1af\" data-element_type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;none&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b798c6e elementor-widget elementor-widget-image\" data-id=\"b798c6e\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"669\" height=\"882\" src=\"https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_5-15.-Evid-Based-2017.jpg\" class=\"attachment-large size-large wp-image-3171\" alt=\"\" srcset=\"https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_5-15.-Evid-Based-2017.jpg 669w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_5-15.-Evid-Based-2017-228x300.jpg 228w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_5-15.-Evid-Based-2017-200x264.jpg 200w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_5-15.-Evid-Based-2017-500x659.jpg 500w\" sizes=\"(max-width: 669px) 100vw, 669px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3116743 e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"3116743\" data-element_type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeInUp&quot;,&quot;animation_delay&quot;:300}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-cd664a9 mb-0 elementor-widget elementor-widget-heading\" data-id=\"cd664a9\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Astragalus Extract Mixture HT042 Improves Bone Growth, Mass, and Microarchitecture in Prepubertal Female Rats: A Microcomputed Tomographic Study\n<\/h5>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5381655 mb-0 elementor-widget elementor-widget-heading\" data-id=\"5381655\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\">Evid Based Complement Alternat Med, 2017\n<\/h6>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0c9ff92 mb-1 elementor-widget elementor-widget-heading\" data-id=\"0c9ff92\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<p class=\"elementor-heading-title elementor-size-default\"><span class=\"fw-bold\">HT042 improves bone mass and bone microstructure as well as bone length growth rate.<\/span><br>\n[Reported that HT042 administration has the effect of accelerating the growth rate of bone length and improving bone mass and microstructure using MicroCT, which can accurately measure 3-dimensional bone length in a living state]<br><br>\nAfter administering HT042 to 21-day-old female SD rats in combination with feed for 2 weeks, 3-dimensional bone length was measured using MicroCT. As a result, bone length was significantly increased to a similar extent to growth hormone.<br> In addition, the bone mass and microstructure of trabecular bone, which are indicators related to the strength and quality of growing bone, were improved.<br><\/p>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e5504d7 e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"e5504d7\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;animation&quot;:&quot;fadeInUp&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-26c84d9 e-con-full e-flex e-con e-child\" data-id=\"26c84d9\" data-element_type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;none&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a66f50c elementor-widget elementor-widget-image\" data-id=\"a66f50c\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"669\" height=\"884\" src=\"https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_5-16.-Evid-Based-2017.jpg\" class=\"attachment-large size-large wp-image-3172\" alt=\"\" srcset=\"https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_5-16.-Evid-Based-2017.jpg 669w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_5-16.-Evid-Based-2017-227x300.jpg 227w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_5-16.-Evid-Based-2017-200x264.jpg 200w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_5-16.-Evid-Based-2017-500x661.jpg 500w\" sizes=\"(max-width: 669px) 100vw, 669px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9b60003 e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"9b60003\" data-element_type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeInUp&quot;,&quot;animation_delay&quot;:300}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-cd54f5e mb-0 elementor-widget elementor-widget-heading\" data-id=\"cd54f5e\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Astragalus Extract Mixture HT042 Increases Longitudinal Bone Growth Rate by Upregulating Circulatory IGF-1 in Rats\n<\/h5>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e5b6996 mb-0 elementor-widget elementor-widget-heading\" data-id=\"e5b6996\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\">Evid Based Complement Alternat Med, 2017\n<\/h6>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3773e43 mb-1 elementor-widget elementor-widget-heading\" data-id=\"3773e43\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<p class=\"elementor-heading-title elementor-size-default\"><span class=\"fw-bold\">HT042 accelerates growth by increasing IGF-1 in the blood.<\/span><br>\n[Reporting that HT042 promotes the expression of IGF-1 and IGFBP-3 mRNA synthesized in the liver by growth hormone, the expression of IGF-1 protein in the blood, and the phosphorylation of JAK2\/STAT5 involved in IGF-1 expression]<br><br>\nAfter oral administration of HT042 to 25-day-old female SD rats for 10 days, IGF-1 blood concentration, liver IGF-1 mRNA expression, and IGFBP-3 mRNA expression were all increased.<br>In addition, stimulated phosphorylation of JAK2\/STAT5, which is a pathway of growth hormone stimulating IGF-1 expression.<br><\/p>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d0463e0 e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"d0463e0\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;animation&quot;:&quot;fadeInUp&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-304bfda e-con-full e-flex e-con e-child\" data-id=\"304bfda\" data-element_type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;none&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c8751a5 elementor-widget elementor-widget-image\" data-id=\"c8751a5\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"669\" height=\"948\" src=\"https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_5-17.-Phytother-Res-2018.jpg\" class=\"attachment-large size-large wp-image-3173\" alt=\"\" srcset=\"https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_5-17.-Phytother-Res-2018.jpg 669w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_5-17.-Phytother-Res-2018-212x300.jpg 212w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_5-17.-Phytother-Res-2018-200x283.jpg 200w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_5-17.-Phytother-Res-2018-500x709.jpg 500w\" sizes=\"(max-width: 669px) 100vw, 669px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3adbb18 e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"3adbb18\" data-element_type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeInUp&quot;,&quot;animation_delay&quot;:300}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e3be442 mb-0 elementor-widget elementor-widget-heading\" data-id=\"e3be442\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Effects of Astragalus Extract Mixture HT042 on Height Growth in Children with Mild Short Stature: A Multicenter Randomized Controlled Trial\n<\/h5>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c885262 mb-0 elementor-widget elementor-widget-heading\" data-id=\"c885262\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\">Phytother Res, 2018\n<\/h6>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8105d15 mb-1 elementor-widget elementor-widget-heading\" data-id=\"8105d15\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<p class=\"elementor-heading-title elementor-size-default\"><span class=\"fw-bold\">HT042 has height growth functionality not only in animal experiments but also in double blind human application trial targeting children.<\/span><br>\n[Reported that intake of HT042 stimulated height growth compared to the control group that consumed placebo, and did not shorten the growth period as it did not affect bone age or sex hormones]<br><br>\nIn a 24-week multicenter, randomized, double blind, human application trial targeting 140 children aged 6-8 years who were 25% shorter in height, the HT042 intake group had a significantly higher amount of height grown during 24 weeks than the placebo intake group.<br>\nIn addition, it was not affect the increase in bone age or the concentration of luteinizing hormone, which are indicators that shorten the growth period.<br>\n<\/p>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9f9b95a e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"9f9b95a\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;animation&quot;:&quot;fadeInUp&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-fdd63dc e-con-full e-flex e-con e-child\" data-id=\"fdd63dc\" data-element_type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;none&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-529cf26 elementor-widget elementor-widget-image\" data-id=\"529cf26\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"669\" height=\"948\" src=\"https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_5-18.-Children-2021.jpg\" class=\"attachment-large size-large wp-image-3174\" alt=\"\" srcset=\"https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_5-18.-Children-2021.jpg 669w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_5-18.-Children-2021-212x300.jpg 212w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_5-18.-Children-2021-200x283.jpg 200w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_5-18.-Children-2021-500x709.jpg 500w\" sizes=\"(max-width: 669px) 100vw, 669px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-fb4f5ea e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"fb4f5ea\" data-element_type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeInUp&quot;,&quot;animation_delay&quot;:300}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4af7f9c mb-0 elementor-widget elementor-widget-heading\" data-id=\"4af7f9c\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Effects of Astragalus Extract Mixture HT042 on Circulating IGF-1 Level and Growth Hormone Axis in Rats\n<\/h5>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5ea6afd mb-0 elementor-widget elementor-widget-heading\" data-id=\"5ea6afd\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\">Children, 2021\n<\/h6>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c75191a mb-1 elementor-widget__width-initial elementor-widget elementor-widget-heading\" data-id=\"c75191a\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<p class=\"elementor-heading-title elementor-size-default\"><span class=\"fw-bold\">HT042 accelerates the growth rate through the growth hormone central axis.<\/span><br>\n[Reported that HT042 increases the expression of growth-stimulating IGF-1 in the blood, pituitary GH, GHRH receptor, GHS receptor, and hypothalamic GHRH and inhibits the expression of hypothalamic GH inhibitory hormone to speed up growth]<br><br>\nAfter oral administration of HT042 to 40-day-old male SD rats, the results were measured: growth factor IGF-1 concentration in blood, liver IGF-1, IGFBP-3 mRNA expression, pituitary GH, GH-secreting GHRH receptor, and GH secretion-stimulating GHS receptor expression and hypothalamic GHRH expression were both increased, and SST hypothalamic expression, which inhibits GH secretion, was suppressed.<br>\nAs a result of measuring the growth rate through the tetracycline calcium fluorescence labeling method, the growth rate was significantly increased to a similar extent to that of growth hormone, and the expression of IGF-1 and BMP-2 in the tibial growth plate was increased.<\/p>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-35e7928 e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"35e7928\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;animation&quot;:&quot;fadeInUp&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-f62278f e-con-full e-flex e-con e-child\" data-id=\"f62278f\" data-element_type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;none&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a6f964c elementor-widget elementor-widget-image\" data-id=\"a6f964c\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"645\" height=\"913\" src=\"https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/\ucea1\ucc98.jpg\" class=\"attachment-large size-large wp-image-3716\" alt=\"\" srcset=\"https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/\ucea1\ucc98.jpg 645w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/\ucea1\ucc98-212x300.jpg 212w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/\ucea1\ucc98-200x283.jpg 200w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/\ucea1\ucc98-500x708.jpg 500w\" sizes=\"(max-width: 645px) 100vw, 645px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ba05add e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"ba05add\" data-element_type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeInUp&quot;,&quot;animation_delay&quot;:300}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e48557f mb-0 elementor-widget elementor-widget-heading\" data-id=\"e48557f\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Astragalus Extract Mixture HT042 Alleviates Dexamethasone-induced Bone Growth Retardation in Rat Metatarsal Bones<\/h5>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-82b761b mb-0 elementor-widget elementor-widget-heading\" data-id=\"82b761b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\">Nutrients. 2024\n<\/h6>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ce97915 mb-1 elementor-widget__width-initial elementor-widget elementor-widget-heading\" data-id=\"ce97915\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<p class=\"elementor-heading-title elementor-size-default\"><span class=\"fw-bold\">HT042 alleviates growth retardation caused by steroid treatments.<\/span><br>\n[Reported to prevent growth retardation by increasing GH and IGF-1 receptor levels reduced by steroid treatments while inhibiting apoptosis]<br><br>\nHT042 activated the Ihh\/PTHrP signaling pathway and increased GHR and IGF-1R expression on the growth plate, which were reduced by DEX. In metatarsal bone and primary chondrocyte models, HT042 promoted growth plate length and reversed DEX-induced growth reduction.<br>HT042 was found to promote cell proliferation through BrdU and TUNEL assays. Its direct action on the growth plate was confirmed by increased GHR\/IGF-1R expression and Ihh\/PTHrP pathway activity, as demonstrated by qRT-PCR, western blot, and siRNA analyses.<br>Additionally, HT042 exhibited anti-apoptotic effects by regulating apoptotic factors such as caspase-3, Bcl2, Bclx, and Bax, as verified in both ex vivo and in vitro models.<\/p>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"false\" data-tab=\"2\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2252\" aria-expanded=\"false\">Safety<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-2252\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2252\" tabindex=\"0\" hidden=\"hidden\">\t\t<div data-elementor-type=\"section\" data-elementor-id=\"3070\" class=\"elementor elementor-3070\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-d3b6d43 sub_company_info_type4_bg elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d3b6d43\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-f7bb0dd\" data-id=\"f7bb0dd\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-db1b0bf elementor-widget__width-initial elementor-invisible elementor-widget elementor-widget-image\" data-id=\"db1b0bf\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;slideInRight&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"580\" height=\"898\" src=\"https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/young-asian-technician-looking-in-microscope-2023-11-27-05-25-05-utc.jpg\" class=\"attachment-large size-large wp-image-3162\" alt=\"\" srcset=\"https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/young-asian-technician-looking-in-microscope-2023-11-27-05-25-05-utc.jpg 580w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/young-asian-technician-looking-in-microscope-2023-11-27-05-25-05-utc-194x300.jpg 194w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/young-asian-technician-looking-in-microscope-2023-11-27-05-25-05-utc-200x310.jpg 200w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/young-asian-technician-looking-in-microscope-2023-11-27-05-25-05-utc-500x774.jpg 500w\" sizes=\"(max-width: 580px) 100vw, 580px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-de0d1fe elementor-invisible\" data-id=\"de0d1fe\" data-element_type=\"column\" data-settings=\"{&quot;animation&quot;:&quot;fadeInRight&quot;,&quot;animation_delay&quot;:200}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-917d932 elementor-widget elementor-widget-text-editor\" data-id=\"917d932\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>We have repeatedly verified that <span style=\"background-color: #fff8b2; line-height: 150%;\">HT042 does not cause precocious puberty, which shortens the growth period.<\/span><\/h4>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f72ac77 elementor-widget elementor-widget-text-editor\" data-id=\"f72ac77\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\tAs experimental methods that can evaluate the induction of precocious puberty, estrogen activity evaluation, steroid synthesis analysis method, and gonadal hypertrophy response test are presented according to OECD standards.<br>\nAccordingly, we conducted animal and cell experiments to confirm that\n<span style=\"font-weight: BOLD;\">\nHT042 has no sex hormone-like action or secretion-stimulating action, and does not affect reproductive organs.<\/span>\n\n<br><br>\nIn the human application test, it was confirmed that <span style=\"font-weight: BOLD;\">it does not increase the secretion of sex hormone (LH) that causes secondary sexual characteristics or increase bone age.<\/span>\n\n<br><br>\n<span style=\"font-weight: BOLD;\">\nThis means that HT042 can help children grow taller without shortening their natural growth period.<\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a204058 elementor-widget elementor-widget-text-editor\" data-id=\"a204058\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\tAstragalus, Acanthopanax senticosus, and Phlomis umbrosa those are main ingredients of HT042 have been widely used to treat various symptoms of children since ancient times.<br>\n\nFor more thorough verification,<span style=\"font-weight: BOLD;\"> we have confirmed that it is safe by conducting 7 GLP toxicity tests, which are the most demanding level for the safety evaluation of pharmaceuticals.<\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a17777e elementor-widget elementor-widget-text-editor\" data-id=\"a17777e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\tRead more below for thorough and credible research results.\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t<div class=\"elementor-element elementor-element-db1e4ce e-flex e-con-boxed e-con e-parent\" data-id=\"db1e4ce\" data-element_type=\"container\" data-core-v316-plus=\"true\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-137c078 e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"137c078\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;animation&quot;:&quot;fadeInUp&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-9091b6b e-con-full e-flex e-con e-child\" data-id=\"9091b6b\" data-element_type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;none&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-736f99e elementor-widget elementor-widget-image\" data-id=\"736f99e\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"669\" height=\"946\" src=\"https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_6-19.-Phytother-Res-2012.jpg\" class=\"attachment-large size-large wp-image-3175\" alt=\"\" srcset=\"https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_6-19.-Phytother-Res-2012.jpg 669w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_6-19.-Phytother-Res-2012-212x300.jpg 212w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_6-19.-Phytother-Res-2012-200x283.jpg 200w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_6-19.-Phytother-Res-2012-500x707.jpg 500w\" sizes=\"(max-width: 669px) 100vw, 669px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-302071a e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"302071a\" data-element_type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeInUp&quot;,&quot;animation_delay&quot;:300}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-09f5fa9 mb-0 elementor-widget elementor-widget-heading\" data-id=\"09f5fa9\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Skeletal growth and IGF levels in rats after HT042 treatment<\/h5>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-042d427 mb-0 elementor-widget elementor-widget-heading\" data-id=\"042d427\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\">Phytother Res, 2012<\/h6>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3d6b706 mb-1 elementor-widget elementor-widget-heading\" data-id=\"3d6b706\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<p class=\"elementor-heading-title elementor-size-default\"><strong>HT042 does not show female hormone-like action or secretion-stimulating action in female rats.<\/strong><br>\n[Reported that HT042 does not promote female hormone secretion and has no similar effect cause it does not change the uterine weight of ovariectomized rats and immature rats]<br><br>\nAccording to the OECD guideline for evaluating estrogenic activity, HT042 was orally administered to 8-week-old female SD rats in which female hormones are not secreted by removing ovaries and immature female SD rats of 17 days of age before female hormones are secreted for 8 weeks and 5 days, respectively. As a result of measuring the weight of the uterus after the test, HT042 did not change the weight of the uterus compared to the control group.<\/p>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5ed736c e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"5ed736c\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;animation&quot;:&quot;fadeInUp&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-48761e5 e-con-full e-flex e-con e-child\" data-id=\"48761e5\" data-element_type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;none&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-fd4767d elementor-widget elementor-widget-image\" data-id=\"fd4767d\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"669\" height=\"889\" src=\"https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_6-20.-Phytomedicine-2017.jpg\" class=\"attachment-large size-large wp-image-3176\" alt=\"\" srcset=\"https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_6-20.-Phytomedicine-2017.jpg 669w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_6-20.-Phytomedicine-2017-226x300.jpg 226w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_6-20.-Phytomedicine-2017-200x266.jpg 200w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_6-20.-Phytomedicine-2017-500x664.jpg 500w\" sizes=\"(max-width: 669px) 100vw, 669px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-36576b0 e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"36576b0\" data-element_type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeInUp&quot;,&quot;animation_delay&quot;:300}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-53505d3 mb-0 elementor-widget elementor-widget-heading\" data-id=\"53505d3\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Safety evaluation of Astragalus extract mixture HT042 and its constituent herbs in Sprague-Dawley rats<\/h5>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e76f5b0 mb-0 elementor-widget elementor-widget-heading\" data-id=\"e76f5b0\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\">Phytomedicine, 2017<\/h6>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a934583 mb-1 elementor-widget elementor-widget-heading\" data-id=\"a934583\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<p class=\"elementor-heading-title elementor-size-default\"><strong>HT042 is a non-toxic and safe ingredient in the GLP toxicity test.<\/strong><br>\n[Reported that HT042 and its constituents are all safe in an acute toxicity test conducted by a GLP institution, and HT042 is safe in a 13-week repeated toxicity test]<br><br>\nIn order to guarantee the reliability of the toxicity test conducted for the safety evaluation of pharmaceuticals, the safety of HT042 and its constituents was tested for single-dose toxicity at the GLP institution that systematically manages the entire test process.<br>\nAs a result, no specific side effects were observed at all doses. Even when the administration period was extended to 13 weeks and a repeated dose toxicity test was conducted, no special side effects were found.<\/p>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-34bdbaf e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"34bdbaf\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;animation&quot;:&quot;fadeInUp&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-87fc803 e-con-full e-flex e-con e-child\" data-id=\"87fc803\" data-element_type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;none&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6209d1a elementor-widget elementor-widget-image\" data-id=\"6209d1a\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"669\" height=\"947\" src=\"https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_6-21.-Phytother-Res-2018.jpg\" class=\"attachment-large size-large wp-image-3177\" alt=\"\" srcset=\"https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_6-21.-Phytother-Res-2018.jpg 669w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_6-21.-Phytother-Res-2018-212x300.jpg 212w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_6-21.-Phytother-Res-2018-200x283.jpg 200w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_6-21.-Phytother-Res-2018-500x708.jpg 500w\" sizes=\"(max-width: 669px) 100vw, 669px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a0ee5a8 e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"a0ee5a8\" data-element_type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeInUp&quot;,&quot;animation_delay&quot;:300}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b08476e mb-0 elementor-widget elementor-widget-heading\" data-id=\"b08476e\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Effects of Astragalus Extract Mixture HT042 on Height Growth in Children with Mild Short Stature: A Multicenter Randomized Controlled Trial<\/h5>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0962923 mb-0 elementor-widget elementor-widget-heading\" data-id=\"0962923\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\">Phytother Res, 2018<\/h6>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1a4c494 mb-1 elementor-widget elementor-widget-heading\" data-id=\"1a4c494\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<p class=\"elementor-heading-title elementor-size-default\"><strong>HT042 has height growth functionality not only in animal experiments but also in double blind human application trial targeting children.<\/strong><br>\n[Reported that intake of HT042 stimulated height growth compared to the control group that consumed placebo, and did not shorten the growth period as it did not affect bone age or sex hormones]<br><br>\nIn a 24-week multicenter, randomized, double blind, human application trial targeting 140 children aged 6-8 years who were 25% shorter in height, the HT042 intake group had a significantly higher amount of height grown during 24 weeks than the placebo intake group.<br>\nIn addition, it was not affect the increase in bone age or the concentration of luteinizing hormone, which are indicators that shorten the growth period.<\/p>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f07365c e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"f07365c\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;animation&quot;:&quot;fadeInUp&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-0dea5bc e-con-full e-flex e-con e-child\" data-id=\"0dea5bc\" data-element_type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;none&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5c8d4f4 elementor-widget elementor-widget-image\" data-id=\"5c8d4f4\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"669\" height=\"895\" src=\"https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_6-22.-Food-Suppl-Biomater-Health-2021.jpg\" class=\"attachment-large size-large wp-image-3178\" alt=\"\" srcset=\"https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_6-22.-Food-Suppl-Biomater-Health-2021.jpg 669w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_6-22.-Food-Suppl-Biomater-Health-2021-224x300.jpg 224w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_6-22.-Food-Suppl-Biomater-Health-2021-200x268.jpg 200w, https:\/\/ht042.co.kr\/en\/wp-content\/uploads\/sites\/5\/2024\/04\/sm_6-22.-Food-Suppl-Biomater-Health-2021-500x669.jpg 500w\" sizes=\"(max-width: 669px) 100vw, 669px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-62ba126 e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"62ba126\" data-element_type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeInUp&quot;,&quot;animation_delay&quot;:300}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3d8be80 mb-0 elementor-widget elementor-widget-heading\" data-id=\"3d8be80\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Effects of Astragalus Extract Mixture HT042 on H295R Steroidogenesis and Hershberger Assay<\/h5>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8e48c3a mb-0 elementor-widget elementor-widget-heading\" data-id=\"8e48c3a\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\">Food Suppl Biomater Health, 2021<\/h6>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-611739a mb-1 elementor-widget elementor-widget-heading\" data-id=\"611739a\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<p class=\"elementor-heading-title elementor-size-default\">[Reporting that HT042 did not affect the secretion of progesterone and estradiol in the steroid synthesis assay, and did not show sex hormone activity or suppression in the gonadal hypertrophy response test]<br><br>\nWhether HT042 causes precocious puberty or not has been studied through human application tests and animal experiments as above, because that if HT042 induces precocious puberty, it may not help the child&#8217;s final height even if the growth rate is accelerated. <br>In this study, H295R adrenocortical cell line, which produces most of the enzymes required for sex hormone synthesis, was treated with HT042, but it did not affect the secretion of female hormones such as progesterone and estradiol.\n<br>In addition, HT042 did not affect blood testosterone and related organs in all groups of normal rats and orchiectomized rats.<br>\n<\/p>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"Functionality Safety Functionality Through various studies, we verified that HT042 improves height growth rate. HT042 How does height grow? \u2460 Growth hormone secreted by the brain synthesizes growth factors in the liver. \u2461 The synthesized growth factor combines with growth protein and \u2462 moves to the growth plate at the tip of the bone. \u2463 [&hellip;]","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_vp_format_video_url":"","_vp_image_focal_point":[],"footnotes":""},"acf":[],"_links":{"self":[{"href":"https:\/\/ht042.co.kr\/en\/wp-json\/wp\/v2\/pages\/2901"}],"collection":[{"href":"https:\/\/ht042.co.kr\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ht042.co.kr\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ht042.co.kr\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ht042.co.kr\/en\/wp-json\/wp\/v2\/comments?post=2901"}],"version-history":[{"count":55,"href":"https:\/\/ht042.co.kr\/en\/wp-json\/wp\/v2\/pages\/2901\/revisions"}],"predecessor-version":[{"id":3637,"href":"https:\/\/ht042.co.kr\/en\/wp-json\/wp\/v2\/pages\/2901\/revisions\/3637"}],"wp:attachment":[{"href":"https:\/\/ht042.co.kr\/en\/wp-json\/wp\/v2\/media?parent=2901"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}